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Research Article Open access CC BY 4.0

Ameliorative Potentials of Egg Plant (Solanum melongena Linn) Fruit Ethanolic Extract on Monosodium Glutamate- Intoxicated Rats' Lipid Profile, Haematology and Heart Histology

Uchendu O. Mbah, Anthony Cemaluk C. Egbuonu

International Journal of Biochemistry Research & Review · pp. 1–10 · Published 9 Aug 2017

10.9734/IJBCRR/2017/35057

Abstract

Aim: This study evaluated the ameliorative potentials of ethanolic extract of Solanum melongena Linn fruit on monosodium glutamate (MSG)-intoxicated rats' lipid profile, haematological parameters and heart histology using standard protocols. Methodology: Twenty four Wistar rats that weighed 105.00 ± 7.00 g. The rats were assigned into six groups and fed thus: Group 1 (control, feed and 1 ml/kg body weight (bw) distilled water only), Group 2 (8000­ mg/kg bw MSG), Group 3 (300 mg/kg bw sample extract), Group 4 (8000 mg/kg bw MSG +100 mg/kg bw sample extract ), Group 5 (8000 mg/kg bw MSG+ 300 mg/kg bw sample extract) and Group 6 (8000 mg/kg bw MSG+ 500 mg/kg bw sample extract) daily for 14 days. Results: There were significant (P =.05) increase in total cholesterol, triacylglyceride (TAG), very low density lipoprotein (VLDL) and low density lipoprotein cholesterol (LDL-c) and significantly (P =.05) decrease in high density lipoprotein cholesterol (HDL-c) in only MSG fed group compared to the control group. Interestingly, MSG co-administration with ethanolic extract of Solanum melongena Linn fruit for group 4, 5 and 6 showed significant (P=.05) reduction in serum total cholesterol, TAG, VLDL and LDL-c and increased HDL-c. There was no significant (P =.05) difference in the haematological parameters (Red blood cell, hemoglobin and hemacrit) except for white blood cell count which was significantly (P =.05) reduced in the MSG fed group. The histological results revealed that MSG ingestion in rats induced toxic injuries in their hearts at 8000 mg/kg body weight and effects were slowly being ameliorated as the concentration of the ethanolic extract of Solanum melongena Linn fruit increased. Conclusion: This study confirmed general adverse influence of MSG at a high concentration (8000 mg/kg body weight) and demonstrated the ameliorative role of ethanolic extract of Solanum melongena Linn fruit, notably at 300 mg/kg of body weight, on the studied monosodium glutamate-intoxicated bio-functions in rats.

Solanum melongena Linn fruit MSG–intoxication lipid profile haematology and heart histology

References (16)

  1. 1 Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge [DOI]
  2. 2 In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension [DOI]
  3. 3 The Safety Evaluation of Monosodium Glutamate [DOI]
  4. 4 The LDL to HDL Cholesterol Ratio as a Valuable Tool to Evaluate Coronary Heart Disease Risk [DOI]
  5. 5 Review of Alleged Reaction to Monosodium Glutamate and Outcome of a Multicenter Double-Blind Placebo-Controlled Study [DOI]
  6. 6 Haematological Study in Response to Varying Doses of Estrogen in Broiler Chicken [DOI]
  7. 7 Monosodium glutamate is not associated with obesity or a greater prevalence of weight gain over 5 years: findings from the Jiangsu Nutrition Study of Chinese adults [DOI]
  8. 8 Protective effect of Piper longum Linn. on monosodium glutamate induced oxidative stress in rats.
  9. 9 Antioxidant and Nutritional Components of Egg plant (Solanum melongena L) Fruit Grown in Saurastra Region
  10. 10 Pulverized Mangifera indica (Mango) Seed-kernel Modulated Serum Lipid Profile in Monosodium Glutamate-challenged Rats [DOI]
  11. 11 Pulverized Mangifera Indica (mango) Seed kernel Mitigated Monosodium Glutamate-Intoxicated rats’ Kidney Histology and Bio-functions [DOI]
  12. 12 SCREENING OF ANTIBACTERIAL ACTIVITY OF SOLANUM MELONGENA SEED EXTRACTS ON SELECTED HUMAN PATHOGENIC BACTERIA
  13. 13 Sub-chronic Concomitant Ingestion of L-arginine and Monosodium Glutamate Improves Feed Efficiency, Lipid Metabolism and Antioxidant Capacity in Male Wistar Rats [DOI]
  14. 14 Sub-Chronic Esculetin (6,7-Dihydroxy-Coumarin)-Induced Alteration in Some Haematological and Serum Parameters in Normal Male Wistar Rats [DOI]
  15. 15 ANALGESIC ACTIVITY OF ROOT EXTRACT OF SOLANUM MELONGENA LINN ROOT
  16. 16 Haemato-Protective and Hypolipidemic Effects of Aqueous Extract of Libyan Propolis Against Sodium Nitrite Induced Haematotoxicity and Hyperlipidemia in Guinea Pigs [DOI]

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