Severe Pulmonary Arterial Hypertension Induced by Dasatinib in a Patient with Chronic Myeloid Leukemia: A Case Report
Siyam Hamady, BOUCETTA Abdullah, OBEIDAT Saleh, Miryem HABOUB, Rachida HABALL
Cardiology and Angiology: An International Journal · pp. 39–44 · Published 20 Aug 2025
10.9734/ca/2025/v14i3497Abstract
Pulmonary arterial hypertension (PAH) is a rare but recognized adverse effect of tyrosine kinase inhibitors, notably Dasatinib, prescribed in chronic myeloid leukemia (CML). Due to potential reversibility, prompt recognition and management are essential. We report a 60-year-old male receiving Dasatinib for CML who presented with NYHA class IV dyspnea. Echocardiography showed severe right ventricular dilation and elevated pulmonary pressures. Right heart catheterization confirmed precapillary PAH. Other causes were ruled out. Following discontinuation of Dasatinib and initiation of combination PAH-specific therapy (epoprostenol, bosentan, tadalafil), the patient demonstrated clinical and hemodynamic improvement. This case highlights the need for vigilance in patients on Dasatinib, especially when respiratory symptoms arise. Early intervention can improve outcomes in drug-induced PAH.
Cited by 0
No indexed citations yet.
Related research
- Risk Factors and Prognosis of Chronic Myeloid Leukemia in Saudi Arabia: A Systematic Review — shares topic coverage
- An Asymptomatic Tropical Infection in a Pregnancy Complicated by a Hematological Neoplasm-accidental Passenger or Effect of Immunosuppression? — shares topic coverage
- Response to Tyrosine Kinase Inhibitors in Patients with BCR-ABL1 Positive Chronic Myeloid Leukemia; 13.5 Years’ Experience at Patan Hospital, Nepal — shares topic coverage
- Intrapulmonary Administration of Autologous Bone Marrow Derived Mononuclear Cells in Congenital Heart Disease Complicated by Pulmonary Arterial Hypertension: A Case Report — shares topic coverage
- Severe Pulmonary Hypertension Secondary to Concomitant Mitral Stenosis with Veno-occlusive Disease in the Context of Systemic Sclerosis: Importance of Careful and Comprehensive Assessment — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.