Assessment of Some Brain Antioxidants Profile in Plasmodium berghei berghei Infected Mice Treated with Ethanol Leaf Extract of Musa paradisiaca

Abstract

Background and Aim: This study evaluated brain antioxidants of locally formulated herbal antimalarial therapy, dry plantain leaf extract (Musa paradisiaca) on mice infected with Plasmodium berghei. Experimental Procedure: Five groups of ten mice each namely control, P. berghei, artesunate, P. berghei infected mice using curative, suppressive and prophylactic models were orally administered with 250 and 1000mg/kg leaf extract of Musa paradisiaca. On the 10th day, the mice were sacrificed and blood samples collected for Catalase, Glutathione Peroxidase (GPX), Glutathione (Glut) and Malondialdehyde (MDA) estimation by standard method. Data was analyzed using SPSS version 21. Results and Conclusion: Catalase (µ/L) was 18.44±1.31, 9.65±0.16, 11.64±1.68, 12.83±0.43, 12.39±0.67, 12.80± 2.20, 9.90± 0.30, 11.54± 0.30, 15.59±0.86, 12.91± 0.33 and 12.0± 0.30, GPX(µ/L) was 63.58±0.62, 19.13±2.4, 42.24±7.15, 17.62±12.70, 55.27±0.50, 42.24±7.15, 17.62±12.70, 55.27±0.50, 37.8±5.20, 39.40± 0.30 and 34.50± 0.50, Glut(µ/m) was 1.05±0.35, 0.61±0.59, 0.67±0.53, 0.74±0.46, 0.94±0.18, 0.67±0.53, 0.74±0.46, 0.94±0.18, 0.74± 0.18, 0.68± 0.40 and 0.81± 0.30 while MDA(µ/m) was 47.9±0.45, 11.2±0.8, 6.4±0.2, 6.0±0.10, 8.30±0.40, 6.4±0.2, 6.0±0.10, 8.3±0.4, 6.10± 0.50, 6.00±0.10 and 5.90± 0.00 in control, P bergei, Artesunate, 250mg, 1000mg, Artesunate, 250mg, 1000mg, Artesunate, 250 mg and 1000 mg curative, Suppressive and prophylactic doses  respectively. Results showed Musa paradisiaca leaf extract protects brain of Plasmodium berghei infected mice from free radicals.