Therapeutic Targets on Toxoplasma gondii Parasite in Combatting Toxoplasmosis
Sharif Alhassan Abdullahi, Ngah Zasmy Unyah, Noshariza Nordin, Rusliza Basir, Wana, Mohammed Nasir, Ashraf, Ahmad Alapid, Yahaya Hassan, Tijjani, Mustapha, Roslaini Abd Majid
Annual Research & Review in Biology · pp. 1–15 · Published 29 Jun 2019
10.9734/arrb/2019/v32i230081Abstract
The status of toxoplasmosis management is challenged by drug intolerance, compromised efficacy and potential development of drug resistance. However, currently, there are very limited targets on T. gondii that serve as the site of action of current medications. This review aimed to explore more potential targets that are essential to parasite survival and are absent in humans. Many unexplored targets on T. gondii exist and their specificities to the parasite make them ideal drug targets. The present review had searched relevant English databases such as PubMed, Scopus, Google scholar and Science Direct, for relevant literature on the therapeutic target of T. gondii. Many of the enzyme systems in several pathways are essentially palatable as drug targets. Establishing compounds that can target these enzymes on T. gondii will greatly be beneficial in treating acute and chronic toxoplasmosis in humans.
Cited by 3
Abbas H. Abdullah, Nada S. Ibrahim, Faisal K. Algethami · Journal of Molecular Structure · 2024
Wagner da S. Terra, Renata V. M. Freitas, Eduardo da S. Neves · Inorganic Chemistry Frontiers · 2026
Alhassan Abdullahi Sharif, Hassan Yahaya · UMYU Scientifica · 2023
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