Anti-stress and Nootropic Activity of Ethanolic Extract of Coriandrum sativum Aerial Parts

Abstract

The swimming endurance test, anoxic tolerance test, and basal activity by actophotometer were used to assess the antistress activity of a seven-day therapy (200 and 400 mg/kg, p.o.) of the ethanolic extract of Coriandrum sativum (EECS) aerial parts. A method for measuring the in vitro antioxidant activity of hydroxyl radicals was used. In all of the examined models, Coriandrum sativum at both doses demonstrated antistress effects. In the anoxic tolerance test, swimming endurance test, and duration of stay on the rotarod, the EECS treated rats demonstrated enhanced swimming time, duration, and anoxic tolerance time, respectively. The C. sativum's potential to scavenge free radicals, which enhanced the cognitive effect, was utilized to determine the in vitro antioxidant activity. The results demonstrated clearly that the extract's in vivo adaptogenic performance and cognitive improvement were caused by its in vitro antioxidant activity. The EECS treated animals showed increase locomotor scores in basal activity by Actophotometer. The plant secondary metabolites flavonoids, glycosides, triterpenoids, and phenolic components may be accountable for the animals' improved swimming endurance, stress tolerance, and overall performance. This study gave evidence that the ethanolic extract of Coriandrum sativum has antioxidant, anti-stress, and nootropic activity, and that utilizing them by humans as nutraceuticals is beneficial and scientific. By stress reduction in animals, the antioxidant effect provides the pharmacological basis for supporting a healthy memory.