Uropathogenic Bacteria and Antimicrobial Sensitivity Pattern among Diabetic Patients with Urinary Tract Infection

Abstract

Urinary tract infection means the presence and active multiplication of microorganisms within the urinary tract that affects any part of urinary tract. A cross sectional descriptive study was conducted on 601 urine sample to determine the antibiotic sensitivity pattern of bacteria causing urinary tract infection in 250 diabetic and 351non-diabetic patients from February 2016 to March 2016. All samples were investigated by standard laboratory procedures. Out of diabetic patient 111 (44.4%) were female and 139 (55.6%) were male and among non-diabetic, 234 (66.7%) were female and 117(33.3%) were male. The UTI prevalence rate was found to be 13% was statistically significant (p= 0.02), among the significant growth 6.8% diabetic and 6.2% non-diabetic. Escherichia coli (54) was the most predominant organism (42.5% in diabetic and 57.5% non-diabetic) followed by Staphylococcus aureus (8). Amikacin, Cotrimoxazole and Nitrofurantoin were most sensitive to E. coli isolated in diabetic and non-diabetic patients among the tested antimicrobials. High rate of resistance was observed with Norfloxacin and Nalidixic acid. Gentamicin, Cefotaxime, Cotrimoxazole and Ciprofloxacin were highly sensitive to S. aureus in diabetic patients while Oxacillin and Azithromycin were resistance and in non-diabetic patient highly sensitive antimicrobials were Azithromycin, Gentamicin, Cefotaxime, Cotrimoxazole, Vancomycin and Ofloxacin while Oxacillin was resistance. The antimicrobial sensitivity testing of uropathogenic bacterial isolates should be performed before the initiation of treatment for UTI. Prevalance of uropathogenic bacteria and resistance rate should be monitored regularly.