Study of Glutathione S Transferases and Malondialdehyde Levels in Male Smokers from Vidharbha Region, India

Abstract

Introduction: Free radicals are compounds having two unpaired electrons. Free radicals oxidize macromolecule in the body, including proteins, nucleic acids, and lipids. The body uses antioxidants to fight free radicals. Antioxidants may come from the diet or be generated internally (endogenous). Endogenous antioxidants include superoxide dismutase, glutathione (GSH), catalase, and glutathione peroxidase. Aim: To study of glutathione s transferases and malondialdehyde (MDA) levels in male smokers from Vidharbha region attending Datta Meghe Medical College Materials and Methods: A minimum sample size of 80 was used with 40 smoking males and 40 non-smoking males. This was a cross-sectional analytical observational analysis conducted in the medical study. Result: The mean GSH concentrations of the smoking and non-smoking research participants were 1.69 ± 0.97 mol/L and 2.20 ± 1.40 mol/L, respectively, when plasma GSH concentrations were measured. Smokers had lower plasma GSH concentrations than non-smokers, but the disparity was not statistically significant (p=0.1885) suggests that smoking has no discernible effect on GSH levels. Conclusion: Smoking tends to reduce plasma GSH while rising plasma MDA levels in men. Owing to a loss of antioxidant potential and a higher oxidative load, smokers are more susceptible to oxidant stress. Young smokers, in particular, should quit smoking as soon as possible before developing health complications in order to reap the full benefits of quitting.